Oxford Science Enterprises is an independent investment company founded in 2015 to bring Oxford University research to market. Operating under an evergreen capital model, the firm has raised over £1.1 billion and deployed more than £850 million to support spinout companies from pre-seed through exit. Oxford University remains a significant shareholder and provides intellectual property from its science departments, while OSE Manager Limited is regulated by the Financial Conduct Authority.
OSE focuses on early-stage funding in three areas: foundational technology, life sciences, and health technology. The firm typically leads rounds with checks ranging from £50,000 to £25 million and remains a consistent backer until exit. By offering strategic guidance, recruitment assistance, and global market expertise, the team helps startups develop innovations in fields such as quantum computing, advanced materials, robotics, next-generation semiconductors, novel therapeutics, and digital health tools.
Within its sustainability policy, OSE supports companies working on clean technology and energy storage solutions. Investments include Oxford Flow, which develops specialized valves to cut fugitive emissions in oil, gas, hydrogen, and carbon capture systems; Mixergy, creator of intelligent hot water tanks that operate as heat batteries; Brill Power, provider of battery management systems that improve safety and performance for stationary storage and electric vehicles; and HydRegen, developer of bio-based catalysts for greener chemical manufacturing. These companies exemplify OSE’s approach to back research-led ventures that enhance energy efficiency, lower emissions, and drive long-term environmental benefits.
